Clinical Trial: A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational

Official Title:

Brief Summary: Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.

Detailed Summary:
Sponsor: The University of Hong Kong

Current Primary Outcome: apnea hypopnea index [ Time Frame: measure at a single time point when the subjects are admitted for overnight polysomnography ]

assess apnea hypopnea index by overnight polysomnography, by a single admission to sleep laboratory


Original Primary Outcome: Same as current

Current Secondary Outcome: endothelial function [ Time Frame: measured at a single time point when the subjects are admitted for overnight polysomnography ]

assess endothelial function by EndoPAT 2000 (an non-invasive device) and peripheral blood endothelial progenitor cells


Original Secondary Outcome: Same as current

Information By: The University of Hong Kong

Dates:
Date Received: October 4, 2010
Date Started: February 2009
Date Completion:
Last Updated: August 1, 2013
Last Verified: August 2013