Clinical Trial: Investigation of Female Reproductive Hormone Dynamics During Adolescence

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Investigation of Female Reproductive Hormone Dynamics During Adolescence

Brief Summary: Irregular menstrual cycles are common in girls for several years after their first menstrual period. The cause of abnormal menstrual cycles during this time is not well-understood. The purpose of this study is to: 1) monitor girls during a menstrual cycle (with blood and urine sampling and serial pelvic ultrasounds) to identify those girls who do not ovulate (release of an egg from the ovary), and 2) determine whether cycles can be corrected by treating girls with a short course of low-dose estrogen and progesterone.

Detailed Summary:
Sponsor: Massachusetts General Hospital

Current Primary Outcome: ovulation in cycle 2 [ Time Frame: 20-40 days ]

serum progesterone > 3 ng/ml or presence of corpus luteum on pelvic ultrasound


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Massachusetts General Hospital

Dates:
Date Received: June 24, 2015
Date Started: April 2015
Date Completion:
Last Updated: June 30, 2015
Last Verified: June 2015