Clinical Trial: Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
Brief Summary: The purpose of this study is to determine the effect of menopause on obesity, energy balance, and insulin in postmenopausal, obese women.
Detailed Summary:
The effect of menopause on body composition and cardiovascular risk in healthy caucasian women has been the subject of much study. In contrast, there are few data available on menopause in African-American women. Since menopause is associated with potentially preventable health risks in women, this proposal is aimed at characterizing the perimenopausal period in terms of body fat, energy balance, and insulin action in both caucasian and African-American women.
The study will address 4 general hypotheses:
- Menopause increases both total and visceral abdominal fat
- Changes in body composition and body weight at menopause are mediated, at least in part by changes in 24-hour energy expenditure and/or food intake
- Menopause results in decreased insulin sensitivity that may predispose certain women to develop diabetes later in life
- African-American women may respond to the shifts in reproductive hormones at menopause differently than caucasian women.
Sponsor: Pennington Biomedical Research Center
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Pennington Biomedical Research Center
Dates:
Date Received: December 14, 2006
Date Started: February 1998
Date Completion:
Last Updated: January 22, 2016
Last Verified: January 2016
