Clinical Trial: Vasopressin and V2 Receptor in Meniere's Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Vasopressin and V2 Receptor in Meniere's Disease
Brief Summary: Summary: Some of sicknesses are well known to be provoked by inadequate adaptation to physical and/or psychogenic stress in their daily life. Meniere's disease is also a common inner ear disease accompanied with vertigo, hearing loss and tinnitus especially in civilized people under stressed life style. Its oto-pathology was firstly revealed in 1938 to be inner ear endolymphatic hydrops through the temporal bone study. To elucidate the neuroscientific relationship between "stress" and "inner ear", we examined plasma vasopressin (the anti-diuretic "stress" hormone) and its receptor, V2R in the endolymphatic sac (the "inner ear" endo-organ for endolymph absorption) in Meniere's patients.
Detailed Summary: Methods: Between 1998 and 2006, we enrolled and assigned 105 intractable Meniere's patients to examine plasma vasopressin during remission of vertigo attacks (controls: 30 patients with chronic otitis media). Using the real-time PCR method, we examined V2R mRNA expression in the endolymphatic sac in 12 patients (controls: 6 patients with acoustic neurinoma). By means of cell culture and cyclic AMP assay, we also examined cyclic AMP activity in the endolymphatic sac in 3 patients (controls: 3 patients with acoustic neurinoma).
Sponsor: Osaka University
Current Primary Outcome: plasma vasopressin level and V2 receptor mRNA in the endolymphatic sac in Meniere's disease vs controls [ Time Frame: prospective ]
Original Primary Outcome: Same as current
Current Secondary Outcome: cyclic AMP activity in the endolymphatic sac in Meniere's disease vs controls [ Time Frame: prospective ]
Original Secondary Outcome: Same as current
Information By: Osaka University
Dates:
Date Received: January 10, 2008
Date Started: April 1998
Date Completion:
Last Updated: March 28, 2016
Last Verified: January 2008
