Clinical Trial: Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Influence of Oral Telithromycin vs. Azithromycin on the Endogenous Microflora in Adults With Acute Sinusitis
Brief Summary: The purpose of this study is to measure the speed of microbial eradication due to azithromycin or telithromycin in acute maxillary sinusitis (AMS).
Detailed Summary:
The objectives of this study are:
- To assess the impact of therapy with telithromycin vs. azithromycin on the oral microflora in patients with acute maxillary sinusitis at day 42 and to compare the duration of colonization with resistant oropharyngeal flora in patients treated with azithromycin vs. telithromycin.
- To also compare the two treatment groups for rate of reinfection within 6 weeks and the susceptibility pattern of the organisms appearing during the reinfection and differences in development of resistance and the associated changes in symptom responses.
Sponsor: CPL Associates
Current Primary Outcome: Bacterial resistance or selection [ Time Frame: 42 days ]
Original Primary Outcome: Bacterial resistance or selection
Current Secondary Outcome: Bacteriologic outcome [ Time Frame: 42 days ]
Original Secondary Outcome: Bacteriologic outcome
Information By: CPL Associates
Dates:
Date Received: October 26, 2005
Date Started: December 2005
Date Completion:
Last Updated: October 29, 2007
Last Verified: October 2007
