Clinical Trial: The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients

Brief Summary: The purpose of the study is to test the effects of metoprolol on anaesthesia and the need for perioperative analgesics in patients undergoing breast surgery. With 12 months follow-up the incidence of pain and life satisfaction will be evaluated.

Detailed Summary: The purpose of the study is to test the effects of intraoperative metoprolol on 1) anaesthetic and alagesic use 2) pain during the early postoperative period and 3) the incidence of pain and lide satisfaction up to 12 months after the surgery. Adverse effects will be recorded as safety measures.
Sponsor: Kuopio University Hospital

Current Primary Outcome:

  • Anaesthesia [ Time Frame: Intraoperative ]
    Total consumption of desflurane
  • Anaesthesia [ Time Frame: Intraoperative ]
    Total consumption of remifentanil
  • Postoperative pain [ Time Frame: First 4 postoperative hours ]
    Total analgesics consumption
  • Postoperative pain [ Time Frame: First 4 postoperative hours ]
    Time to analgesics
  • Postoperative pain [ Time Frame: First 4 postoperative hours ]
    Numerical pain scale (0 = no pain, 10 = most pain) at rest and at movement
  • Long-term pain [ Time Frame: 3 months ]
    The incidence and the level of pain at 3 months
  • Long-term pain [ Time Frame: 1 year ]
    The incidence and the level of pain at 12 months


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Safety and tolerability [ Time Frame: Perioperative ]
    Number of patients with adverse effects
  • Distribution to the central nervous system [ Time Frame: Perioperative ]
    Cerebro spinal fluid and blood samples
  • Life satisfaction [ Time Frame: 1 year ]
    Life satisfaction in a Likerts scale
  • Anxiety [ Time Frame: 1 year ]
    Spielberg State-Trait Anxiety Inventory
  • Depression [ Time Frame: 1 year ]
    Beck Depression Inventory


Original Secondary Outcome: Same as current

Information By: Kuopio University Hospital

Dates:
Date Received: September 19, 2014
Date Started: October 2017
Date Completion: December 2017
Last Updated: November 1, 2016
Last Verified: November 2016