Clinical Trial: Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Cardiovascular Impact of Obstructive Sleep Apnea in Normotensive Patients and the Effects of Continuous Positive Airway Pressure

Brief Summary: Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension. However, there are few data regarding the impact of OSA on the preHypertension and Masked Hypertension in apparently normotensive patients with OSA as well as the impact of treatment with continuous positive airway pressure.

Detailed Summary:
Sponsor: University of Sao Paulo

Current Primary Outcome: Office Blood Pressure

Evaluation of PreHypertension


Original Primary Outcome: Blood pressure measurements (24-hour ambulatory blood pressure measurements) [ Time Frame: Baseline and after 3 months. ]

Current Secondary Outcome: 24 Hour Ambulatory Blood Pressure Monitoring

Evaluation of Masked Hypertension


Original Secondary Outcome:

  • urine volume and microalbuminuria [ Time Frame: Baseline and after 3 months. ]
  • arterial stiffness [ Time Frame: Baseline and after 3 months ]
  • Baroreflex sensitivity [ Time Frame: Baseline and after 3 months ]
  • Blood pressure response during treadmill testing [ Time Frame: Baseline and after 3 months ]
  • Sympathetic activity [ Time Frame: Baseline and after 3 months ]


Information By: University of Sao Paulo

Dates:
Date Received: August 25, 2008
Date Started: August 2008
Date Completion:
Last Updated: October 27, 2010
Last Verified: August 2008