Clinical Trial: Antihypertensive Treatment in Masked Hypertension for Target Organ Protection

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title:

Brief Summary:

The primary purpose of the study is to estimate the target organ protection after 12 months of antihypertensive treatment in masked hypertension patients with at least one kind of target organ damage (left ventricular hypertrophy, large arterial stiffness and microalbuminuria). Improvement was defined as the relevant parameter back to normal or declined at least 20%.

The secondary objectives include: blood pressure lowering effect, target organ damage parameters improvement, and the incidence rate of all cause death and cardiovascular events (stroke and myocardia infraction).


Detailed Summary:
Sponsor: Yan Li

Current Primary Outcome: Improvement rate of target organ damage (left ventricular hypertrophy, large arterial stiffness and microalbuminuria) [ Time Frame: 1 year ]

Improvement was defined as the relevant parameters (Cornell voltage combination, Sokolow-Lyon index, microalbuminuria/creatinine ratio, brachial-ankle pulse wave velocity) back to normal or declined at least 20%.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • 24h ambulatory blood pressure [ Time Frame: 1 year ]
  • electrocardiogram [ Time Frame: 1 year ]
    calculating Cornell voltage combination and Sokolow-Lyon index
  • microalbuminuria/creatinine ratio [ Time Frame: 1 year ]
  • brachial-ankle pulse wave velocity [ Time Frame: 1 year ]
  • incidence rate of all cause death and cardiovascular events (stroke and myocardia infraction) [ Time Frame: 1 year ]


Original Secondary Outcome: Same as current

Information By: Shanghai Institute of Hypertension

Dates:
Date Received: August 31, 2016
Date Started: November 2016
Date Completion:
Last Updated: September 2, 2016
Last Verified: September 2016