Clinical Trial: Epidemiology and Control of Mansonella Perstans Infection in Uganda
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda
Brief Summary: Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.
Detailed Summary:
Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control
Specific objectives:
- To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
- To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
- To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.
Sponsor: DBL -Institute for Health Research and Development
Current Primary Outcome:
- microfilariae periodicity patterns
- epidemiology of M. perstans at community level
- clinical spectre among infected
- reduction in microfilaraemia
Original Primary Outcome: Same as current
Current Secondary Outcome: treatment effect on clinical manifestations
Original Secondary Outcome: Same as current
Information By: DBL -Institute for Health Research and Development
Dates:
Date Received: September 21, 2005
Date Started: November 2005
Date Completion: February 2006
Last Updated: April 19, 2007
Last Verified: April 2007
