Clinical Trial: A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia

Brief Summary: The purpose of the study is to develop methods to identify predictors of Malignant Hyperthermia.

Detailed Summary: The current study will use the combination of electronic medical records and genomic information in samples of persons who have exhibited signs of Malignant Hyperthermia (MH) or have family history or high risk of MH to see if risk factors can be identified. These will be compared with control samples of children who have been exposed to the same agents which could induce MH, yet showed no signs of the disorder.
Sponsor: Children's Hospital Medical Center, Cincinnati

Current Primary Outcome: Number of clinical manifestations of malignant hyperthermia [ Time Frame: Within data collection period (3 years total). ]

Incidence of clinical manifestations of MH will be compared among patients with a history of MH to controls (no diagnosis of MH).


Original Primary Outcome: Same as current

Current Secondary Outcome: number of Genetic indications for malignant hyperthermia [ Time Frame: Within data collection period (3 years total). ]

genetic indications for malignant hyperthermia will be compared between control subjects and subjects with a diagnosis of MH


Original Secondary Outcome: Same as current

Information By: Children's Hospital Medical Center, Cincinnati

Dates:
Date Received: July 27, 2015
Date Started: May 2014
Date Completion: May 2017
Last Updated: July 25, 2016
Last Verified: July 2016