Clinical Trial: Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Clinical Trial of Extended-dose Chloroquine Versus Standard Chloroquine Treatment for Resistant Falciparum Malaria Among Afghan Refugees in NWFP Pakistan
Brief Summary: The purpose of this study was to provide stronger evidence for extended-dose chloroquine treatment of falciparum-positive Afghan refugees in Northwest Frontier Province (NWFP), Pakistan or justification for discontinuation of the policy.
Detailed Summary: To determine whether extended-dose chloroquine provided better cure rates and fewer recrudescences than standard chloroquine treatment among Afghan refugees, 163 falciparum patients from three Afghan refugee camps were recruited into 3-day (CQ 25mg/kg) or 5-day (CQ 40mg/kg) treatment arms and followed for up to 60 days.
Sponsor: London School of Hygiene and Tropical Medicine
Current Primary Outcome: therapeutic and parasitological cure with no recrudescence [ Time Frame: 60 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- parasite clearance time [ Time Frame: 28 days ]
- fever clearance time [ Time Frame: 28 days ]
- gametocytaemia [ Time Frame: 28 days ]
Original Secondary Outcome: Same as current
Information By: London School of Hygiene and Tropical Medicine
Dates:
Date Received: November 23, 2009
Date Started: November 1993
Date Completion:
Last Updated: November 23, 2009
Last Verified: November 2009
