Clinical Trial: Severe and Cerebral Malaria Investigated Through Host Metabolomics
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational
Official Title: Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics
Brief Summary:
- The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
- Despite treatment between 10-30% of patients with severe malaria die.
- Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
- Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.
Detailed Summary:
Sponsor: University of Oxford
Current Primary Outcome: Characterisation of patterns of metabolic dysregulation in severe malaria [ Time Frame: 4-6 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of Oxford
Dates:
Date Received: May 15, 2015
Date Started: June 2015
Date Completion: September 2018
Last Updated: May 19, 2015
Last Verified: May 2015