Clinical Trial: Severe and Cerebral Malaria Investigated Through Host Metabolomics

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics

Brief Summary:

  • The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
  • Despite treatment between 10-30% of patients with severe malaria die.
  • Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
  • Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

Detailed Summary:
Sponsor: University of Oxford

Current Primary Outcome: Characterisation of patterns of metabolic dysregulation in severe malaria [ Time Frame: 4-6 weeks ]

Interrelationship between disturbances in metabolic pathways associated with acidosis and cerebral malaria


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Oxford

Dates:
Date Received: May 15, 2015
Date Started: June 2015
Date Completion: September 2018
Last Updated: May 19, 2015
Last Verified: May 2015