Clinical Trial: School Based Malaria Control in Ugandan Schoolchildren

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: School-based Malaria Control: Impact of Intermittent Preventive Treatment on Malaria Morbidity and Cognitive Function in Ugandan School Childr

Brief Summary: The investigators hypothesize that schoolchildren treated with IPT using DP over one year of follow-up will have a different risk of clinical malaria compared to those treated with placebo.

Detailed Summary:
Sponsor: Makerere University

Current Primary Outcome:

• Risk of Clinical Malaria [ Time Frame: 1 year ]
  Fever(temperature greater or equal to 37.5 degrees centigrade or history of fever in past 24 hours) in presence of parasitemia.
• Cognitive function tests [ Time Frame: 1 year ]
  Mean score in the cognitive function tests (Raven's Matrices test and Code transmission test)

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Risk of parasitemia [ Time Frame: 1 year ]
  presence of asexual parasites on blood smear
• Risk of hospital admissions [ Time Frame: 1 year ]
  Admission of any cause
• Risk of adverse events [ Time Frame: 1 year ]
  Any untoward medical occurrence in a participant taking study medication
• School performance [ Time Frame: 1 year ]
  Average position in class as reported in the end of the year school report
• Prevalence of anemia [ Time Frame: 1 year ]
  Proportion of hemoglobin measurements < 10 g/dL.

Original Secondary Outcome: Same as current

Information By: Makerere University

Dates:
Date Received: October 29, 2010
Date Started: February 2011
Date Completion:
Last Updated: May 22, 2013
Last Verified: May 2013