Clinical Trial: Machado-Joseph Disease in Israel

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Machado-Joseph Disease in Israel: Clinical Phenotype and Genotype of a Jew Yemenite Subpopulation

Brief Summary: Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA-3) is the most common dominant ataxia. The genetic cause of this late-onset degenerative disorder is the expansion of a (CAG)n tract located in the exonic region of the ATXN3 gene. In 1994 the first case of MJD among the Yemenite Jewish subpopulation living in Israel was published. The puropse of this study is to describe the clinical phenotype and genotype of the Yemenite Jewish subpopulation with MJD living in Israel

Detailed Summary:
Sponsor: Meir Medical Center

Current Primary Outcome: clinical phenotype of SCA3 Yemenite Jews patients [ Time Frame: 3 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Meir Medical Center

Dates:
Date Received: June 22, 2014
Date Started: June 2014
Date Completion: June 2018
Last Updated: March 15, 2017
Last Verified: April 2016