Clinical Trial: Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Brief Summary: Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.

Detailed Summary:
Sponsor: National Center for Research Resources (NCRR)

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: National Center for Research Resources (NCRR)

Dates:
Date Received: January 16, 2001
Date Started:
Date Completion:
Last Updated: June 23, 2005
Last Verified: December 2003