Clinical Trial: Specific Autoantibody Testing in Patients With Interstitial Lung Disease
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: To Evaluate the Clinical Utility of Specific Autoantibody Testing in Patients With Interstitial Lung Disease
Brief Summary: The purpose of this study is to evaluate the clinical utility of specific autoantibody testing in unmasking an underlying connective tissue disorder in patients who present with interstitial lung disease and found to have weak positive ANA (1:400 titre) with no overt connective tissue disease manifestations OR borderline/negative ANA with some clinical suggestion of connective tissue disease.
Detailed Summary: It has been well established that patients with connective tissue disease associated interstitial lung disease respond better to immunosuppressive therapy, and have a better outcome compared to patients with idiopathic interstitial pneumonias. This makes it imperative to identify this group of patients for management and prognostication. Unfortunately some of these patients do not demonstrate overt clinical manifestations of connective tissue disease and our current available autoantibody screen does not detect all potential autoantibodies present. We would like to test for specific autoantibodies in this group of patients to evaluate its clinical utility in identifying covert connective tissue diseases associated with interstitial lung disease.
Sponsor: Singapore General Hospital
Current Primary Outcome: Clinical utility of specific autoantibody testing [ Time Frame: 3 months ]
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Singapore General Hospital
Dates:
Date Received: May 15, 2012
Date Started: May 2012
Date Completion: April 2017
Last Updated: October 27, 2016
Last Verified: October 2016
