Clinical Trial: Tau Imaging in Young Onset Dementia

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: [18F]-T807 PET/CT Imaging of Tau Pathology in Young Onset Focal Dementia

Brief Summary: The central goal of this study is to determine and compare the similarities and differences in regional brain uptake of [18F]T807 in patients with typical Alzheimer's Disease (AD), Posterior Cortical Atrophy (PCA), and Logopenic Variant of Primary Progressive Aphasia (lvPPA). The investigators will correlate patterns of [18F]T807 binding with magnetic resonance imaging (MRI)-based regional volumetric and cortical thickness measures. If cerebral spinal fluid (CSF) samples are not available, patients may be asked to get an optional lumbar puncture (LP) for additional comparisons. The investigators will recruit 20 participants, 45-70 years old, with clinical evidence of young onset focal dementia.

Detailed Summary:
Sponsor: University of Pennsylvania

Current Primary Outcome:

  • Determine and compare the similarities and differences in regional brain uptake of [18F]T807 by using standardized uptake value ratio (SUVr) in patients with typical AD, PCA and lvPPA [ Time Frame: 2 years ]
  • Correlate patterns of [18F]T807 binding based on standardized uptake value ratio (SUVr) with MRI-based regional volumetric (mm3) and cortical thickness (mm) measures [ Time Frame: 2 years ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Correlate CSF markers of amyloid (Aβ1-42) and/or tau (total tau, phospho-tau) pathology (pg/mL) to uptake of [18F]T807 based on standardized uptake value ratio (SUVr). [ Time Frame: 2 years ]
  • Correlate [18F]T807 binding based on standardized uptake value ratio (SUVr) with standard cognitive tests. [ Time Frame: 2 years ]
    Neurocognitive test results


Original Secondary Outcome: Same as current

Information By: University of Pennsylvania

Dates:
Date Received: November 5, 2014
Date Started: November 2014
Date Completion: December 2018
Last Updated: March 29, 2017
Last Verified: March 2017