Clinical Trial: Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

Brief Summary: The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes. The most common of these syndromes is Marfan Syndrome (MFS), but several other recognized aortopathy syndromes are well characterized. The investigators propose the use of a simple blood test, from which miRNA profiles can be measured in individuals with aortopathy syndromes to be compared with miRNAs observed in a control population that has no known predisposition for aortic disease. The investigators hypothesize that microRNA profiles in individuals with Marfan syndrome, and related disorders, will be distinct from those seen in a control group. The investigators predict that up- or down-regulation of certain miRNAs will correlate with the presence and severity of aortic aneurysm, responses to medical therapy, and ultimately could be used to determine when an individual may be at risk of dissection.

Detailed Summary:
Sponsor: University of Colorado, Denver

Current Primary Outcome:

  • Plasma miRNA profiling in individuals with Marfan syndrome [ Time Frame: 2 years ]
    In a cross-sectional analysis, characterize circulating miRNA profiles in individuals with Marfan syndrome and compare to profiles in normal age-matched controls.
  • Plasma miRNA profiling in individuals with aortopathy syndromes [ Time Frame: 3 years ]
    In a cross-sectional analysis, characterize circulating miRNA profiles in individuals with aortopathy syndromes and compare to profiles in normal age-matched controls.


Original Primary Outcome: Same as current

Current Secondary Outcome: Correlation of plasma miRNA profiles with aortic dimensions [ Time Frame: 2 years ]

In a cross-sectional analysis correlate miRNA profiles with aortic dimension and Z-score, type of medication used, history of aneurysm and/or dissection, and need for surgical intervention in individuals with MFS.


Original Secondary Outcome: Same as current

Information By: University of Colorado, Denver

Dates:
Date Received: August 7, 2014
Date Started: July 1, 2014
Date Completion:
Last Updated: March 14, 2017
Last Verified: March 2017