Clinical Trial: Influence of Adiponutrin in Chronic Liver Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Study of Metabolism Influence in Human Alcoholic Liver Disease

Brief Summary: Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

Detailed Summary:
Sponsor: Erasme University Hospital

Current Primary Outcome: Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.

After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Erasme University Hospital

Dates:
Date Received: May 11, 2010
Date Started: January 2003
Date Completion:
Last Updated: May 11, 2010
Last Verified: December 2002