Clinical Trial: Pangenomic Study During Alcoholic Cirrhosis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis

Brief Summary:

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.


Detailed Summary:
Sponsor: Nantes University Hospital

Current Primary Outcome: Existence of HCC and Pangenomic analysis of DNA polymorphism

Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC


Original Primary Outcome: Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC

Current Secondary Outcome: cirrhosis severity (compensated or not)

Analysis of the genetic polymorphism involved in the severity of cirrhosis


Original Secondary Outcome: cirrhosis severity (compensated or not)

Information By: Nantes University Hospital

Dates:
Date Received: February 8, 2010
Date Started: May 2008
Date Completion: May 2012
Last Updated: August 12, 2011
Last Verified: April 2010