Clinical Trial: Sitosterolemia Metabolism

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Assessment of Sterol Metabolism in Sitosterolemia: A Pilot Study of Patients Treated With Ezetimibe

Brief Summary: Ezetimibe has become the treatment choice for patients with sitosterolemia. Ezetimibe is an inhibitor of cholesterol absorption from the gastrointestinal tract. The purpose of this study is to determine if ezetimibe improves whole body plant sterol and cholesterol homeostasis.

Detailed Summary:
Sponsor: University of Manitoba

Current Primary Outcome:

• Plasma cholesterol level [ Time Frame: 8 months ]
  Plasma cholesterol level will be assessed by GC
• Plasma sitosterol level [ Time Frame: 8 months ]
  Plasma plant sterol assessment using GC

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Cholesterol absorption [ Time Frame: 4 month ]
  Use stable isotope technique to assess cholesterol absorption
• Cholesterol synthesis [ Time Frame: 4 months ]
  Use of stable isotope to assess cholesterol synthesis.

Original Secondary Outcome: Same as current

Information By: University of Manitoba

Dates:
Date Received: April 16, 2012
Date Started: April 2012
Date Completion: December 2016
Last Updated: March 9, 2016
Last Verified: December 2015