Clinical Trial: Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly Diagnosed

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly Diagnosed

Brief Summary:

The knowledge of encephalitis associated with antibodies targeting intracellular antigens, and neuronal surface antibody syndromes has expanded considerably in recent times.

The primary purpose of the investigators protocole is to determine the incidence of anti-neuronal antibodies (blood and CSF) in a population of patients suffering from focal epilepsy of unknown cause to guide the management of these patients.

The investigators hypothesis is that dysimmune encephalitis is more common than is suggested by the current literature, and that sometimes forms of encephalitis dysimmune "at minimum" can be observed only in the form of focal epilepsy without further manifestation associated.


Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

Current Primary Outcome: anti-neuronal antibodies [ Time Frame: 2 years ]

Incidence of seropositive patients for anti-neuronal antibodies in a cohort of patients with focal epilepsy of unknown cause.


Original Primary Outcome: Same as current

Current Secondary Outcome: statistically significant differences between people with and without-neuronal antibodies differences [ Time Frame: 2 years ]

Related to population characteristics: age, sex, ethnicity, handedness, immune dysfunction associated field, psychiatric field associated migraine associated


Original Secondary Outcome: Same as current

Information By: University Hospital, Strasbourg, France

Dates:
Date Received: October 9, 2014
Date Started: June 2015
Date Completion: July 2017
Last Updated: August 25, 2016
Last Verified: August 2016