Clinical Trial: Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes

Brief Summary: This study is evaluating Whole Body MRI as a possible screening tool to diagnose cancer for people with LFS and other inherited cancer predisposition syndromes.

Detailed Summary:

Individuals who carry the TP53 mutation have a higher risk of developing different types of cancer over their lifetimes. This gene has been associated with Li Fraumeni syndrome in some families, but not all families that have cancer histories consistent with Li Fraumeni syndrome will have the mutation. Currently, there is no standard method of monitoring LFS carriers, family members, or others individuals with cancer predisposition syndromes to detect cancers in the early stages, when they may be more easily treated.

The main aim of the study is to test a relatively new medical technology called Whole Body Magnetic Resonance Imaging (MRI), in patients with these syndromes, to see if cancers can be detected at an early stage which may, in turn, allow for more effective treatment. The investigators have chosen Whole Body MRI scanning because this scan allows doctors to look at the entire body in one examination. By using this technology, participants are not exposed to radiation, which is of particular importance for individuals who have a higher cancer risk due to a diagnosis of LFS.


Sponsor: Dana-Farber Cancer Institute

Current Primary Outcome: Return of pediatric and adult patients with Li Fraumeni Syndrome year-after-year for 2 annual scans. [ Time Frame: 2 years ]

Successful return of patients for two annual scans will be recorded.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Return of pediatric and adult patients with other cancer predisposition syndromes year-after-year for 2 annual scans. [ Time Frame: 2 years ]
    Successful return of patients for two annual scans will be recorded.
  • Detection of prevalent and incident cancers on WB-MRI in pediatric and adult patients with Li Fraumeni and other inherited cancer predisposition syndromes. [ Time Frame: 3 years ]
    Tabulation of all follow-up imaging studies, biopsies, and cancer diagnoses will be pursued.
  • Detection of prevalent and incident cancers on additional screening studies in pediatric and adult patients with Li Fraumeni and other inherited cancer predisposition syndromes. [ Time Frame: 3 years ]
    Tabulation of all follow-up imaging studies, biopsies, and cancer diagnoses will be pursued.


Original Secondary Outcome: Same as current

Information By: Dana-Farber Cancer Institute

Dates:
Date Received: October 11, 2016
Date Started: March 2012
Date Completion: September 2021
Last Updated: October 31, 2016
Last Verified: October 2016