Clinical Trial: Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of CPB-leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function.

Brief Summary: To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury

Detailed Summary:

BACKGROUND AND OBJECTIVES: The extension of the systemic inflammatory response observed after cardiopulmonary bypass (CPB) in cardiac surgery is associated to postoperative pulmonary dysfunction degree. The leukocyte depletion during CPB can modify that response. The aim of this study was to evaluate the effects of leukocyte filtering on the inflammatory response and lung function in patients undergoing coronary artery bypass grafting.

METHODS: After approval by the institutional ethical committee, a prospective randomized study was performed to compare nine patients undergoing coronary artery bypass grafting (CABG) using leukocyte filtration in the arterial line (LG-6, Pall Biomedical Products) and eleven others submitted to standard CPB. Chest CT, oxygenation analysis and a complete leucocyte count were performed before surgery. After intravenous anesthesia induction, patients were mechanically ventilated with tidal volume of 8 mL.kg-1, with FiO2 0.6, and PEEP of 5 cm H2O, except during CPB. Haemodynamic data, PaO2/FiO2, shunt fraction, interleukins, elastase and myeloperoxidase were evaluated before and after CPB, at the end of surgery, 6, 12 and 24 hours after surgery. Chest CT was repeated on the first postoperative day. Data were analyzed using two-factor ANOVA for repeated measures.


Sponsor: University of Sao Paulo

Current Primary Outcome: Effects of CPB-leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function. [ Time Frame: 24 hours ]

The primary outcome was the evaluation of the effects of leukocyte filtration on lung function in patients undergoing coronary surgery.


Original Primary Outcome: Same as current

Current Secondary Outcome: Evaluation of the effects of leukocyte filtration on the inflammatory response in patients undergoing coronary surgery. [ Time Frame: 24 hours ]

The secondary outcome was the evaluation of the effects of leukocyte filtration on the inflammatory response in patients undergoing coronary surgery.


Original Secondary Outcome: Same as current

Information By: University of Sao Paulo

Dates:
Date Received: June 22, 2011
Date Started: February 2007
Date Completion:
Last Updated: November 9, 2011
Last Verified: November 2011