Clinical Trial: The Relationship Between White Matter Hyperintensity With Cognition and Emotion
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: The Relationship Between White Matter Hyperintensity With Cognition and Emotion
Brief Summary: White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.
Detailed Summary:
Sponsor: Zhejiang University
Current Primary Outcome:
- Fazekas Scale of white matter hyperintensity [ Time Frame: 1 year ]
- Mini-Mental State Examination (MMSE) [ Time Frame: 1 year ]
- Hamilton Depression Scale (HAMD) [ Time Frame: 1 year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Zhejiang University
Dates:
Date Received: May 2, 2016
Date Started: January 2014
Date Completion: December 2017
Last Updated: May 2, 2016
Last Verified: May 2016
