Clinical Trial: Demonstration of the Dynamic Hypothesis of Latent Tuberculosis Infection
Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational
Official Title: Demonstration of the Dynamic Hypothesis of Latent Tuberculosis Infection
Brief Summary: It is traditionally considered that the development of Latent Tuberculosis Infection (LTBI) is due to the M. tuberculosis ability to develop a dormancy state within well-structured lesions (granulomas), which can remain in the lung of the host even for life. A new original hypothesis has been developed in the Experimental Tuberculosis Unit based on scientific evidence that take into account the idea that a lesion cannot be held forever, because the host tends to remove any lesion in order to rebuild the original parenchyma, in a healing process. Even if M. tuberculosis can remain in a dormant/non-replicating state for a long period, this is an important but not sufficient factor to explain the LTBI. The Dynamic Hypothesis tries to explain the existence of LTBI in spite of the healing process that could remove it by a constant reinfection of the host's tissue. While the "Static" view defends the induction of active TB after the reactivation of the bacilli from and old lesion; while the "Dynamic" view wants to demonstrate that there is a constant induction of new granulomas. In case one of these new lesions takes place in the upper lobe privileged zone, the possibility to induce a cavity would appear, developing an active Tuberculosis (TB).
Detailed Summary:
Sponsor: Germans Trias i Pujol Hospital
Current Primary Outcome:
- QuantiFeron-Gold-In Tube method assay [ Time Frame: Every 6 months during 3 years ]
- Detection of M.tuberculosis DNA and RNA in the exhaled breath condensate [ Time Frame: Once every year (every 6 months if possible), during 3 years ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Germans Trias i Pujol Hospital
Dates:
Date Received: May 19, 2009
Date Started: May 2009
Date Completion: December 2011
Last Updated: July 8, 2011
Last Verified: November 2009
