Clinical Trial: Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients
Brief Summary: The purpose of this study is to evaluate the efficacy of rabeprazole (pariet) versus placebo in treating reflux laryngitis in Chinese patients. Patients who attend the voice clinic of Department of ENT, Queen Mary hospital with suspected reflux laryngitis will be recruited. A questionnaire will be administered by the research assistant of the Department of Medicine and ENT, Queen Mary hospital. A 12-week course of PPI versus placebo trial will be commenced and patients' symptoms and signs will be documented at 6-week and 12-week time. The study will finish after a 12-week course of rabeprazole.
Detailed Summary:
Sponsor: Hospital Authority, Hong Kong
Current Primary Outcome: Symptoms assessment, quality of life. [ Time Frame: 12 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Compliance [ Time Frame: 4 weeks ]
- Adverse effects [ Time Frame: 4 weeks ]
Original Secondary Outcome: Same as current
Information By: Hospital Authority, Hong Kong
Dates:
Date Received: August 15, 2007
Date Started: January 2005
Date Completion:
Last Updated: October 22, 2013
Last Verified: October 2013
