Clinical Trial: The Effect of Intravenous Lidocaine on Post-extubation Laryngospasm

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Effect of Intravenous Lidocaine on the Incidence of Post-extubation Laryngospasm: A Randomised Controlled Trial

Brief Summary:

In the literature, we found no randomized clinical trials addressing the using of IV lidocaine as prophylaxis for postoperative laryngospasm among adults.

The aim of this study was to assess the effects of IV lidocaine on the incidence of postoperative laryngospasm of adults patients.


Detailed Summary:

During anesthesia practice, one of the common complications of airway management is laryngospasm. The etiology of laryngospasm is unknown but may be due to insufficient depth of anesthesia during tracheal intubation, light plane of anesthesia during tracheal extubation, pain, or presence of airway irritant like laryngoscope blade, irritated volatile agent, suction catheter, surgical debris, mucus, blood, or other foreign body. Laryngospasm occurs in both genders and all ages. Incidence of laryngospasm was reported to the Australian incident monitoring study (AIMS) was 5% with of 22% of them without an attributable cause.

Currently, there is no proven prophylaxis for laryngospasm and the known treatments of laryngospasm are used post-occurrence. However, elimination of factors that lead to laryngospasm is the most indispensable item for reduction of its incidence.

Intravenous (IV) lidocaine interrupts nerve conduction by blocking sodium channels. Recent meta-analysis study showed that IV lidocaine was able to prevent laryngospasm in children. However, in the literature, we found no randomized clinical trials addressing the using of IV lidocaine as prophylaxis for postoperative laryngospasm among adults.

The aim of this study was to assess the effects of IV lidocaine on the incidence of postoperative laryngospasm of adults patients.


Sponsor: King Saud University

Current Primary Outcome: Number of Patients With Laryngospasm Postoperatively [ Time Frame: within first 15 minutes post‐dose ]

There were 4 scores of laryngospasm:

0 = No Laryngospasm

  1. = Stridor or partial laryngospasm
  2. = Complete Laryngospasm
  3. = Cyanosis


Original Primary Outcome: Number of Patients With Laryngospasm Postoperatively [ Time Frame: within first hour post‐dose ]

Current Secondary Outcome:

Original Secondary Outcome:

  • Number of patients had incidence of nausea and vomiting postoperatively [ Time Frame: 0, 1, 2 hours post‐dose ]
  • Number of Patients With Incidence of Cough Postoperatively [ Time Frame: within first hour post‐dose ]
  • Change in pain severity postoperatively [ Time Frame: 0, 1, 2 hours post‐dose ]
  • Number of patients with incidence of aggressive behavior postoperatively [ Time Frame: 0,1,2 hours post‐dose ]


Information By: King Saud University

Dates:
Date Received: September 29, 2011
Date Started: January 2012
Date Completion:
Last Updated: April 9, 2017
Last Verified: April 2017