Clinical Trial: The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title:
Brief Summary:
In clinical practice language impairment is frequently reported in association with nocturnal epileptiform activity. There is a spectrum of epileptic conditions that are characterized by nocturnal epileptiform activity. From mild to severe this spectrum involves: Rolandic epilepsy (RE), nocturnal frontal lobe epilepsy (NFLE), Landau-Kleffner syndrome (LKS) and electrical status epilepticus during slow wave sleep (ESES). The exact characteristic of the relationship between nocturnal epileptiform activity and language impairment is yet to be explored. The investigators suggest that nocturnal epileptiform EEG discharges and nocturnal epileptic seizures during development will cause diseased neuronal networks that involve language. The diseased neuronal networks are less efficient compared with normal neuronal networks.
Objective: Identification of a diseased neuronal network characteristic in children with nocturnal epileptiform activity, which can explain language impairment in these children. For this the investigators will use functional magnetic resonance imaging (MRI) to analyse brain activity and diffusion weighted MRI to investigate white matter connectivity.
Detailed Summary:
Sponsor: Maastricht University Medical Center
Current Primary Outcome: Mechanism that causes language problems in childhood epilepsy [ Time Frame: course of study ]
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Maastricht University Medical Center
Dates:
Date Received: April 13, 2011
Date Started: October 2010
Date Completion:
Last Updated: September 22, 2015
Last Verified: September 2015