Clinical Trial: Psychological Outcomes in Isolated GnRH Deficiency

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Psychological Outcomes in Isolated GNRH Deficiency

Brief Summary:

Background:

- Isolated (or Congenital) GnRH Deficiency (IGD) is a rare disease. People who have this go through puberty late. Some never reach puberty or don t complete it without treatment. They also may have an impaired sense of smell or other health problems. Research shows that disorders like this can have a negative effect on a person s psychological profile.

Objective:

- To understand the psychological outcomes in people with IGD. These can include depression, anxiety, poor health, and poor social function.

Eligibility:

• Adults age 18 and over with IGD. They must be currently on a full dose of hormone replacement therapy for at least 3 months.
• Healthy adult volunteers.

Design:

• Participants will get a username and password. This will give them access to questions online. They can do this from any computer connected to the Internet.
• Participants will log in and complete the questionnaires. There are 5 total, but they will appear as 1 continuous set of questions. Answering them takes about 1 hour or less.
• The first set is about the participant s disorder. The rest ask about depression, anxiety, global health, and social function.
• All answers will be used for research and to better understand reproductive disorders. Only researchers from the NIH Unit on Genetics of Puberty and Reproduction and from this study will know which answers belong to which participant.

Detailed Summary:

Isolated GnRH Deficiency (IGD) is a rare disorder characterized by decreased secretion of GnRH, resulting in impaired gonadotropin secretion and subsequent impaired sex-steroid production. Patients with this rare clinical syndrome present with absent, delayed, or stalled pubertal development by eighteen years of age. In addition, non-reproductive phenotypes of this spectrum have been identified in some individuals, including anosmia, auditory and ocular defects, and skeletal, neurological, and renal anomalies.

Due to the complex heterogeneity among affected individuals and the rarity of the disease itself, the phenotypic spectrum has not been fully investigated. The relationship between psychological disorders and IGD remains largely unexplored as a phenotypic association, despite evidence that disorders of puberty and reproduction can have a negative impact on the psychological profile.

This study aims to conduct a preliminary investigation into the association between psychological symptoms and IGD. We plan to recruit adult patients with a diagnosis of IGD to complete online assessments that measure psychological health outcomes from the patient perspective in order to gauge the prevalence of negative emotional states among affected individuals, compared to healthy controls. This will determine whether further studies are necessary to investigate psychiatric disease as part of the phenotypic spectrum of the disorder, and will improve our understanding of this complex disorder as a whole. Greater knowledge of the psychological impact of IGD may impact the current standards of evaluation and treatment of patients with delayed pubertal maturation.


Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


Current Primary Outcome: The primary outcome is to identify whether patients with Isolated GnRH Deficiency have a higher prevalence of negative emotional states, including depression, anxiety, poor social function and quality of life, than healthy controls. [ Time Frame: End of study ]



Original Primary Outcome: Same as current



Current Secondary Outcome:



Original Secondary Outcome:

Information By: National Institutes of Health Clinical Center (CC)


Dates:
Date Received: February 4, 2015
Date Started: January 27, 2015
Date Completion: June 23, 2017
Last Updated: April 21, 2017
Last Verified: December 7, 2016