Clinical Trial: Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism

Brief Summary:

The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic Hypogonadism (IHH).

The investigators hypothesize that normalizing testosterone levels in men with IHH enhances insulin sensitivity, reduces visceral fat, increases lean body mass, and improves the lipid profile.

Detailed Summary:
Sponsor: Massachusetts General Hospital

Current Primary Outcome:

• Change in glucose tolerance [ Time Frame: Change between baseline and 3 months ]
  Response to 75 g glucose load
• Change in insulin sensitivity [ Time Frame: Change between baseline and 3 months ]
  IV glucose tolerance test

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Change in visceral fat [ Time Frame: Change between baseline and 3 months ]
  Assessed by CT of abdomen
• Change in resting energy expenditure [ Time Frame: Change between baseline and 3 months ]
  Assessed by metabolic monitor

Original Secondary Outcome: Same as current

Information By: Massachusetts General Hospital

Dates:
Date Received: July 14, 2010
Date Started: May 2010
Date Completion:
Last Updated: April 17, 2017
Last Verified: April 2017