Clinical Trial: Sequential Therapy for Hypogonadotropic Hypogonadism

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy and Safety of Human Chorionic Gonadotropin (HCG) and Follicle Stimulating Hormone (FSH) in the Treatment of Hypogonadotropic Hypogonadism

Brief Summary: The traditional therapy for induction of spermatogenesis in male hypogonadotropic hypogonadism requires both HCG and human menopausal gonadotropin (HMG) or FSH until pregnancy occurs. Because of the high cost of hMG or FSH preparations and poor compliance, the investigators raise a new sequential therapeutic approach which can make the treatment more economic and tolerable. The zinc supplement will be also evaluated in patients in this study. This randomized, parallel, open, and multi-center study will compare the efficacy of traditional therapy with new therapy and evaluate the safety of the new protocol.

Detailed Summary:
Sponsor: Shanghai Jiao Tong University School of Medicine

Current Primary Outcome: Sperm density ≥1,000,000/ml [ Time Frame: One and a half year ]

The sperm will be counted as equal or more than 1,000,000/ml under microscope for each subject.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Shanghai Jiao Tong University School of Medicine

Dates:
Date Received: February 1, 2011
Date Started: September 2009
Date Completion:
Last Updated: February 10, 2014
Last Verified: February 2014