Clinical Trial: Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using Platelet-rich Fibrin : A Pilot Randomized Controlled Trial

Brief Summary: This study evaluates the clinical effect of regenerative endodontic procedure using PRF in immature permanent teeth with apical periodontitis. Half of participants will receive the PRF instead of blood clots in the regenerative endodontic procedure, while the other half will receive a blood clots in the regenerative endodontic procedure.

Detailed Summary: The conventional method of regenerative endodontic procedure using a blood clot as scaffold materials has shown successful results. However, it is very difficult to induce bleeding and place mineral trioxide aggregate over a blood clot. Platelet-rich fibrin (PRF), a second-generation platelet concentrate. PRF is a matrix of autologous fibrin containing a large quantity of platelets, growth factors and leukocytes. PRF preparation technique is very simple, inexpensive and doesn't require any chemical agents. The purpose of this study is to test the hypothesis that the use of PRF in regenerative endodontic procedure of immature permanent teeth with apical periodontitis will accelerate periapical bone healing and stimulate the root maturation.
Sponsor: Fujian Medical University

Current Primary Outcome: Evidence of periapical healing [ Time Frame: 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Evidence of root development [ Time Frame: 24 months ]
  • Evidence of pulp sensibility [ Time Frame: 24 months ]
    a positive response to pulp sensibility tests include cold test and electric pulp testing


Original Secondary Outcome:

  • Evidence of root development [ Time Frame: 24 months ]
  • Evidence of pulp sensibility [ Time Frame: 24 months ]
    a positive response to pulp sensibility tests include cold test and EPT


Information By: Fujian Medical University

Dates:
Date Received: June 12, 2016
Date Started: May 2013
Date Completion: February 2017
Last Updated: June 16, 2016
Last Verified: June 2016