Clinical Trial: Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Brief Summary:

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.


Detailed Summary: resting state fMRI scan light therapy the second time resting state fMRI scan
Sponsor: Hangzhou Normal University

Current Primary Outcome: amplitude of low-frequency fluctuation change before and after light treatment [ Time Frame: before and after light treatment ]

It is indicator of blood oxygenation level dependent.


Original Primary Outcome: Same as current

Current Secondary Outcome: cerebral blood flow change before after light treatment [ Time Frame: before and after light treatment ]

It is indicator of arterial spin labeling.


Original Secondary Outcome: Same as current

Information By: Hangzhou Normal University

Dates:
Date Received: August 20, 2014
Date Started: August 2014
Date Completion: July 2015
Last Updated: August 21, 2014
Last Verified: August 2014