Clinical Trial: Acute MRI in Transient Ischemic Attack

Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Acute MRI-techniques for the Detection of Ischemic Lesions After Transient Ischemic Attack

Brief Summary:

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.


Detailed Summary:

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA.

Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care:

  1. 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease.
  2. Axial T2 FLAIR to detect white matter lesions.
  3. Axial DWI to detect areas with impeded diffusion.

(Total scantime 10min)

If no signs of ischemic lesions is detected the following additional research scan-protocol will be initiated:

  1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia.
  2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions.

(Total additional scantime 10min)

All in All 20min in the scanner.


Sponsor: Bispebjerg Hospital

Current Primary Outcome: frequency of patients with ischaemic lessions on DTI [ Time Frame: on first MRI ]

We want to assess the frequency of patients in whom a diffusion restricted lesion can only be observed on DTI


Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Bispebjerg Hospital

Dates:
Date Received: February 9, 2012
Date Started: January 2012
Date Completion:
Last Updated: July 15, 2014
Last Verified: July 2014