Clinical Trial: Iron Overload in Stem Cell Transplant Recipients

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Impact of Iron Overload in Pediatric Patients Undergoing Stem Cell Transplantation

Brief Summary: The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe that the iron status in these patients is associated with complications for transplant survivors. We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine.

Detailed Summary:
Sponsor: Boston Children’s Hospital

Current Primary Outcome: Hepatic iron content as measured by R2 MRI. [ Time Frame: Pre-HSCT and Day 100 ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Genetic determinants of iron overload- HFE status. [ Time Frame: Pre-HSCT ]

Original Secondary Outcome: Same as current

Information By: Boston Children’s Hospital

Dates:
Date Received: December 10, 2008
Date Started: February 2007
Date Completion:
Last Updated: June 22, 2011
Last Verified: June 2011