Clinical Trial: Non-invasive Quantification of Liver Iron With MRI

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Non-invasive Quantification of Liver Iron With MRI

Brief Summary: The purpose of this study is to validate magnetic resonance imaging as a biomarker of hepatic iron concentration (HIC). Excessive accumulation of iron in the body is highly toxic, specifically in the liver. Accurate, non-invasive assessment of HIC is needed for diagnosis, quantitative staging and treatment monitoring or hepatic iron overload.

Detailed Summary: Excessive accumulation of iron in the body can result from abnormal intestinal absorption in hereditary hemochromatosis or repeated intravenous blood transfusions (ie: transfusional hemosiderosis). Excess body iron is highly toxic, and requires treatment aimed at reducing body iron stores. Measurement of body iron stores is critical for detection of iron overload, staging its severity and monitoring of iron-reducing therapies that are often extremely expensive (>$40,000/year) and carry their own toxicities. MRI has been shown to be very sensitive to the presence of iron. The investigators have developed an MRI-based method for rapid iron quantification (for instance, whole liver in a single breath-hold). The purpose of this work is to validate this new method using the FDA-approved Ferriscan technique (Resonance Health, Claremont, Australia) as a reference standard.
Sponsor: University of Wisconsin, Madison

Current Primary Outcome: Accuracy and robustness of non-contrast R2*-MRI for measuring hepatic iron concentration [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome: Same as current

Information By: University of Wisconsin, Madison

Dates:
Date Received: March 16, 2015
Date Started: April 2015
Date Completion:
Last Updated: June 16, 2015
Last Verified: June 2015