Clinical Trial: Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
Brief Summary: The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.
Detailed Summary:
Sponsor: Rennes University Hospital
Current Primary Outcome: serum hepcidin levels [ Time Frame: over 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- urinary hepcidin levels [ Time Frame: over 24 hours ]
- serum iron and ferritin levels [ Time Frame: over 24 hours ]
Original Secondary Outcome: Same as current
Information By: Rennes University Hospital
Dates:
Date Received: May 27, 2008
Date Started: March 2008
Date Completion: February 2009
Last Updated: May 29, 2008
Last Verified: May 2008
