Clinical Trial: Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception: A Randomized Controlled Trial

Brief Summary:

Intussusception is one of the most frequent causes of acute bowel and second most common cause of acute abdominal pain in pediatric age .95 % of cases are idiopathic, the rest are either due to pathological lead point or post operative. Treatment of intussusception must start with medical resuscitation, then radiological or operative reduction of intussusception.

Our surgery team has used hydrocortisone with the medical resuscitation to improve the success rate of pneumatic reduction and decrease the number of reduction trials.


Detailed Summary:

Experimental group will be given single dose IV Hydrocortisone 10 mg/kg with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Control group will be given Saline 100 ml IV single injection with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.


Sponsor: Cairo University

Current Primary Outcome: Success of Pneumatic Reduction [ Time Frame: 1 Hour ]

Comparing number of Successful Pneumatic Reductions in both groups


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Reducing number of trials of Pneumatic Reduction [ Time Frame: 2 Hours ]
    Comparing average number of Pneumatic Reduction trials between both groups
  • Reducing complications [ Time Frame: 2 Hours ]
    Comparing number of complications in both groups


Original Secondary Outcome: Same as current

Information By: Cairo University

Dates:
Date Received: February 22, 2016
Date Started: April 2015
Date Completion: December 2017
Last Updated: February 5, 2017
Last Verified: February 2017