Clinical Trial: The Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: The Relation Between the Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection

Brief Summary: The purpose of this study is to find a correlation between function of cytomegalovirus -specific T cells and the probability for intrauterine transmission.

Detailed Summary:

Fetal infection with CMV is the most common cause of intrauterine infection. Only 40% of pregnant women with primary CMV transmit the virus to their fetus. Many of these women are referred to amniocentesis and many elect to terminate pregnancy without knowledge about fetal infection or damage. Currently it is assumed that transmission is dictated by variety of factors including maternal and fetal immune system. Efforts to find correlation between maternal immune system and fetal infection which can be used as a diagnostic marker were unsuccessful.

Our hypothesis is that there is a correlation between cellular immune response of the mother to CMV infection and viral transmission to the fetus.

Pregnant women with primary CMV infection (40% of whom are expected to be transmitters)and with pre-conception immunity will participate in this study.

Blood from these women will be incubated with CMV peptides and T cell activation will be measured by the secretion of various cytokines.

Sponsor: Shaare Zedek Medical Center

Current Primary Outcome: Maternal-Fetal transmission of CMV [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Shaare Zedek Medical Center

Dates:
Date Received: March 4, 2010
Date Started: February 2012
Date Completion: August 2014
Last Updated: February 20, 2012
Last Verified: February 2012