Clinical Trial: VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF

Brief Summary: The investigators study the VEGF signaling in ICC cell lines／human tissues and its mechanism in HCC growth, proliferation and apoptosis.

Detailed Summary: Several studies have documented the elevated expression of VEGF and its receptors in ICC cell lines and tumor tissues. Another study observed that the elevation of VEGF promotes the growth. Clinical analyses have discovered the high expression of VEGF is correlated with tumor progression, vascular invasion, distal metastasis and poor prognosis. However, few studies have been conducted to investigate the VEGF signaling in ICC cells and its possible mechanism in regulating ICC growth.Therefore,we try to clarify the mechanism of VEGF signal in ICC growth,proliferation and apoptosis.
Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Current Primary Outcome: the variation of the quantity of VEGF signal pathway genes in normal liver tissue,peri tumor,tumor and metastasis. [ Time Frame: the day when conducting surgery (day 1) ]

the sections would be collected as previously described.Western blot,immunohistochemistry,PCR would be conducted to find out the variation between the normal liver tissue and tumor,tumor and meta(if have).


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: First Affiliated Hospital, Sun Yat-Sen University

Dates:
Date Received: August 5, 2013
Date Started: October 2012
Date Completion: December 2014
Last Updated: August 5, 2013
Last Verified: August 2013