Clinical Trial: Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension

Brief Summary: The purpose of this study is to estimate the intracranial pressure (ICP, the pressure in your head) in subjects with intracranial hypotension (a condition caused by leakage of the fluid that surrounds your brain and spine) using non-invasive magnetic resonance imaging (MRI) techniques, and to determine whether changes in estimated ICP are seen after treatment of this condition.

Detailed Summary:
Sponsor: Duke University

Current Primary Outcome:

  • Intracranial pressure measurements estimated by the MRICP technique. [ Time Frame: Approximately scan time will be 30 minutes ]
  • Cerebro spinal fluid pressure measured by lumbar puncture [ Time Frame: During lumbar procedure upto 2 hours ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in Intracranial pressure estimated with MR technique [ Time Frame: Baseline, 24 hours ]
  • Change in caliber to the transverse venous sinus caliber [ Time Frame: Baseline, 24 hours ]
  • Change in flow velocity through the transverse dural venous sinus [ Time Frame: Baseline, 24 hours ]


Original Secondary Outcome: Same as current

Information By: Duke University

Dates:
Date Received: February 1, 2017
Date Started: June 15, 2017
Date Completion: December 31, 2017
Last Updated: May 1, 2017
Last Verified: May 2017