Clinical Trial: Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension
Brief Summary: Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?
Detailed Summary: traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours
Sponsor: University Hospital, Grenoble
Current Primary Outcome: intracranial pressure [ Time Frame: 2 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- transcranial doppler [ Time Frame: 2 h ]
- brain PO2 [ Time Frame: 2h ]
- MAP [ Time Frame: 2h ]
- Heart Rate [ Time Frame: 2h ]
- biology (blood gases, natremia, hematocrit) [ Time Frame: 2h ]
- diuresis [ Time Frame: 2h ]
- fluid requirement [ Time Frame: 2h ]
Original Secondary Outcome: Same as current
Information By: University Hospital, Grenoble
Dates:
Date Received: November 20, 2008
Date Started: October 2008
Date Completion:
Last Updated: November 7, 2012
Last Verified: November 2012