Clinical Trial: Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension

Brief Summary: Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?

Detailed Summary: traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours
Sponsor: University Hospital, Grenoble

Current Primary Outcome: intracranial pressure [ Time Frame: 2 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • transcranial doppler [ Time Frame: 2 h ]
  • brain PO2 [ Time Frame: 2h ]
  • MAP [ Time Frame: 2h ]
  • Heart Rate [ Time Frame: 2h ]
  • biology (blood gases, natremia, hematocrit) [ Time Frame: 2h ]
  • diuresis [ Time Frame: 2h ]
  • fluid requirement [ Time Frame: 2h ]


Original Secondary Outcome: Same as current

Information By: University Hospital, Grenoble

Dates:
Date Received: November 20, 2008
Date Started: October 2008
Date Completion:
Last Updated: November 7, 2012
Last Verified: November 2012