Clinical Trial: Cerebral Microembolism During Hemodialysis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Quantity, Quality and Laterality of Cerebral Microembolism During Veno-Venous Hemodialysis.

Brief Summary:

There is increasing evidence that renal replacement therapy (= continuous veno-venous hemodialysis) generates cerebral microembolism which is detectable on transcranial Doppler ultrasound.

The aim of this study is to monitor patients with transcranial Doppler under two conditions: during hemodialysis and in a hemodialysis-free interval (in each period cerebral embolic load is detected during 30 minutes).

The study hypothesis is that during hemodialysis the cerebral embolic load is significantly higher than in the hemodialysis-free interval.


Detailed Summary:
Sponsor: Medical University of Vienna

Current Primary Outcome: Quantity of cerebral embolic load [ Time Frame: 30 minutes ]

Cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.


Original Primary Outcome: Cerebral embolic load [ Time Frame: 30 minutes ]

Cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.


Current Secondary Outcome: Quality and laterality of cerebral embolic load [ Time Frame: 30 minutes ]

Quality (solid vs. gaseous) and laterality (left vs. right hemispheric dominance) of cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.


Original Secondary Outcome: Quality of cerebral embolic load [ Time Frame: 30 minutes ]

Quality of cerebral embolic load (solid vs. gaseous) is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.


Information By: Medical University of Vienna

Dates:
Date Received: November 20, 2013
Date Started: September 2013
Date Completion:
Last Updated: March 3, 2016
Last Verified: March 2016