Clinical Trial: Immune Modulation From Trichuris Trichiura

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Mucosal and Systemic Immune Modulation From Trichuris Trichiura in a Self-infected Individual

Brief Summary: Mucosal immunology during helminth infection

Detailed Summary: The present study investigates the effects of Trichuris trichiura on human mucosal and systemic immunity in a single self-infected individual.
Sponsor: University of Aarhus

Current Primary Outcome: Faecal egg excretion [ Time Frame: 30 weeks ]

Weekly monitoring of fecal egg counts by microscopy


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Mucosal T cell associated cytokines [ Time Frame: Week 15 ]
    Biopsy sampling during established infection
  • Systemic immune parameters (eosinophilia, Subtypes of circulating T cells) [ Time Frame: 30 weeks ]
    Weekly monitoring
  • Adverse events [ Time Frame: 30 weeks ]
    The included individual was monitored clinically every week for the development of diarrhea and weight loss, and by blood samples for anemia and inflammatory parameters every other week.


Original Secondary Outcome: Same as current

Information By: University of Aarhus

Dates:
Date Received: March 12, 2015
Date Started: February 2012
Date Completion:
Last Updated: November 18, 2016
Last Verified: November 2016