Clinical Trial: Immune Modulation From Trichuris Suis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Mucosal and Systemic Immune Modulation From Trichuris Suis in a Self-infected Individual

Brief Summary: Mucosal immunology during helminth infection

Detailed Summary: The present study investigates the effects of Trichuris suis on human mucosal and systemic immunity in a single self-infected individual.
Sponsor: University of Aarhus

Current Primary Outcome: Faecal egg excretion [ Time Frame: 15 weeks ]

Weekly monitoring of fecal egg counts by microscopy


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Mucosal T cell associated cytokines [ Time Frame: 15 weeks ]
    Biopsy sampling during established infection
  • Systemic immune parameters (eosinophilia, Subtypes of circulating T cells) [ Time Frame: 15 weeks ]
    Blood samples every week
  • Adverse events [ Time Frame: 15 weeks ]
    Clinical evaluation every week


Original Secondary Outcome: Same as current

Information By: University of Aarhus

Dates:
Date Received: March 9, 2017
Date Started: August 1, 2012
Date Completion:
Last Updated: March 9, 2017
Last Verified: March 2017