Clinical Trial: Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

Brief Summary: The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.

Detailed Summary: Several studies have shown that strength training can promote important benefits for the cardiovascular system in healthy subjects and patients with chronic diseases. However, the effects of resistance exercise on cardiovascular function in intermittent claudication patients are unclear. In addition, it also do not know the chronic effects on cardiovascular function in these patients.
Sponsor: University of Pernambuco

Current Primary Outcome: Change in blood pressure [ Time Frame: Change from baseline to 12 and 24 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in Walking distance [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in Health related Quality of life [ Time Frame: Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks ]
  • Change in Muscle blood flow of limbs [ Time Frame: Change from baseline to 12 and 24 weeks ]
    Muscle blood flow assessed with venous occlusion plethysmography
  • Change in body fat [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change Serum Cholesterol [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in serum glucose [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in TNFalpha [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in Score Short-physical performance battery [ Time Frame: Change from baseline to 12 and 24 weeks ]


Original Secondary Outcome:

  • Change in Walking distance [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in Helth related Quality of life [ Time Frame: Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks ]
  • Change in Muscle blood flow of limbs [ Time Frame: Change from baseline to 12 and 24 weeks ]
    Muscle blood flow assed with venous occlusion pletismography
  • Change in body fat [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change Serum Cholesterol [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in serum glucose [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in TNFalpha [ Time Frame: Change from baseline to 12 and 24 weeks ]
  • Change in Score Short-physical performance battery [ Time Frame: Change from baseline to 12 and 24 weeks ]


Information By: University of Pernambuco

Dates:
Date Received: December 12, 2013
Date Started: January 2010
Date Completion:
Last Updated: May 23, 2016
Last Verified: May 2016