Clinical Trial: Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor

Brief Summary:

The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in patients with brain tumors is limited to supratentorial tumors. Due to their anatomic location, posterior fossa tumors result in obstruction of ventricular outflow, produce hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical positions themselves affect systemic hemodynamics which may influence cerebral blood flow; with presence of anesthetics further compromising the blood flow to the brain. Understanding the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of patients and maintenance of intraoperative hemodynamic.

The aim of this observational study was to evaluate CA and CO2R in patients with posterior fossa tumor prior to surgical decompression of the lesion.

Detailed Summary:
Sponsor: All India Institute of Medical Sciences, New Delhi

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: All India Institute of Medical Sciences, New Delhi

Dates:
Date Received: November 18, 2011
Date Started: July 2012
Date Completion:
Last Updated: November 21, 2011
Last Verified: November 2011