Clinical Trial: Melatonin Study Between Diminished and Normal Responder in IVF

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Comparison of IVF Outcome and Endometrium Effect in Infertility Patients Between Diminished and Normal Ovarian Reserve After Melatonin Administration.

Brief Summary: Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. Many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. The investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress.

Detailed Summary:
Sponsor: Bundang CHA Hospital

Current Primary Outcome:

  • IVF outcome - oocyte quality [ Time Frame: 3 days after oocyte retrieval ]
    Evaluate oocyte quality on morphological standard as follwing catagory- Mature oocyte, Imtermediate oocyte, atretic oocyte, post mature oocyte
  • IVF outcome - embryo quality [ Time Frame: 3 to 5 days after oocyteretrieval ]
    grade the embryos& blastocysts according to the Lucinda Veeck & Gardner
  • IVF outcome -biochemical pregnancy rate [ Time Frame: on day 12~14 after embyo transfer ]
    serum hCG level>10 IU
  • IVF outcome - clinical pregnancy rate [ Time Frame: at 6-8 weeks of gestation ]
    presence of G-sac in the uterine cavity


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • acquired oocyte No [ Time Frame: 20weeks ]
    number
  • fertilization rate [ Time Frame: 20weeks ]
    ratio of no. of fertilized egg/ no of total retreived eggs
  • Compairing Pittsburgh sleep quality index [ Time Frame: 20weeks ]
    questionairs to evaluate the participants quality of the sleep. cut off : 13 points This questionaire is to be asked to the participants twice, before and after the administration of the drug
  • marker(melatonin level, receptor, 8-OHdg) in serum, follicular fluid and endometrium during IVF [ Time Frame: 20weeks ]
    :pg/ml units are used


Original Secondary Outcome: Same as current

Information By: Bundang CHA Hospital

Dates:
Date Received: April 4, 2017
Date Started: April 30, 2017
Date Completion: February 28, 2018
Last Updated: April 12, 2017
Last Verified: April 2017