Clinical Trial: Hypercapnia: Cognitive Effects and Monitoring
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Hypercapnia: Cognitive Effects and Monitoring
Brief Summary:
The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses:
- An algorithm can be developed which predicts cognitive performance in immersed exercising divers, based on the exhaled carbon dioxide (PETCO2) and the diver's inspired partial pressures of oxygen and nitrogen (PIO2 and PIN2).
- PETCO2 using mass spectrometry is an accurate estimate of arterial carbon dioxide (PaCO2) at rest and during immersed exercise and can be used as a PaCO2 surrogate at levels exceeding 50 mmHg and depths up to 158 fsw (gas density 6.4 g/l, similar to 165 fsw density of 6.8 g/l).
Detailed Summary:
Sponsor: Duke University
Current Primary Outcome: Is cognitive ability different while resting versus compared to cognitive ability while diving, breathing different gas mixtures and while exercising? [ Time Frame: pre-dive to dive to post-dive (approximately 2 hours) ]
Original Primary Outcome: Same as current
Current Secondary Outcome: How does exhaled (end tidal) carbon dioxide compare with arterial carbon dioxide? [ Time Frame: pre-dive to dive to post dive (approximately 2 hours) ]
Original Secondary Outcome: Same as current
Information By: Duke University
Dates:
Date Received: January 31, 2013
Date Started: January 2013
Date Completion:
Last Updated: May 24, 2016
Last Verified: May 2016